"Tyra mail!" the model tweeted, referencing the way messages are given to contestants of the show. "Thinking #ANTM22 should be our last cycle. I truly believe it's time. May your pics be forever fierce. Keep on smizing! Tyra."
Banks, who has served as chief panellist alongside a changing array of famous fashion faces, first launched the show in 2003, and has seen the franchise replicated globally with various degrees of success.
The model, who studied at harvard Business School while filming the show, has gone on to have several other successful forays into television - including her own talk show, The Tyra Banks Show, and new panel show The FABLifewith Chrissy Teigen.